Tag: TMP-SMX warfarin interaction

Trimethoprim-Sulfamethoxazole and Warfarin: Why INR Rises and What to Do

Trimethoprim-Sulfamethoxazole and Warfarin: Why INR Rises and What to Do

Trimethoprim-sulfamethoxazole can cause dangerous INR spikes in warfarin users, increasing bleeding risk. Learn why this interaction happens, who's most at risk, and what to do if you're prescribed both.

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