Metformin for PCOS: What You Need to Know About Dosage, Side Effects, and Results

When it comes to managing metformin, an oral medication originally developed for type 2 diabetes that’s now widely used to treat polycystic ovary syndrome. Also known as Glucophage, it helps your body use insulin more effectively—something many women with PCOS, a hormonal disorder affecting up to 1 in 10 women of reproductive age, characterized by irregular periods, excess androgens, and ovarian cysts. It’s not a cure, but it’s one of the most studied and prescribed tools for improving symptoms like weight gain, acne, and infertility.

PCOS often goes hand-in-hand with insulin resistance, a condition where cells don’t respond well to insulin, causing the body to produce more of it, which in turn drives testosterone production and disrupts ovulation. Metformin breaks that cycle. It doesn’t just lower blood sugar—it can help restore regular periods, reduce unwanted hair growth, and even improve chances of getting pregnant. Studies show that women with PCOS taking metformin are more likely to ovulate than those on placebo, and when combined with lifestyle changes, results are even stronger. Many women notice improvements in energy and weight within weeks, though full effects can take 3 to 6 months.

Side effects like nausea, bloating, and diarrhea are common at first, but they usually fade as your body adjusts. Starting with a low dose—often 500 mg once daily—and slowly increasing helps most people tolerate it better. It’s not for everyone: people with kidney problems, severe liver disease, or those who drink heavily should avoid it. And while it’s often used alone, many doctors pair it with other treatments like clomiphene for ovulation induction or birth control pills to regulate cycles. What’s clear is that metformin isn’t just a diabetes drug anymore—it’s become a cornerstone in the long-term management of PCOS, especially for those struggling with metabolic issues.

Below, you’ll find real-world insights from people who’ve used metformin for PCOS, along with guides on how to handle side effects, when to expect results, and what to watch out for when mixing it with other medications. Whether you’re just starting out or have been on it for a while, there’s something here to help you make smarter, safer choices.