Prilosec: What It Is, How It Works, and Alternatives You Should Know

When you’re dealing with constant heartburn or acid reflux, Prilosec, a proton pump inhibitor that reduces stomach acid production. Also known as omeprazole, it’s one of the most widely used medications for managing gastroesophageal reflux disease (GERD) and ulcers. Unlike antacids that just mask symptoms, Prilosec works at the source — blocking the tiny pumps in your stomach lining that produce acid. This means longer relief, often for up to 24 hours after just one dose.

But Prilosec isn’t the only option. Many people switch to other proton pump inhibitors, a class of drugs that target stomach acid at the cellular level like Nexium (esomeprazole) or pantoprazole. Others try H2 blockers like Zantac or Pepcid, which work differently but can still reduce acid. Then there are natural approaches — diet changes, avoiding trigger foods, or even elevating your head while sleeping. The key is finding what fits your body and lifestyle, not just what’s advertised.

Prilosec is available over-the-counter, but that doesn’t mean it’s risk-free. Long-term use has been linked to nutrient deficiencies, especially magnesium and vitamin B12. Some studies show a slight increase in bone fracture risk with extended use, especially in older adults. And if you’re taking other meds — like blood thinners or certain antibiotics — Prilosec can interfere. Always talk to your doctor before using it for more than two weeks straight.

What you’ll find below is a collection of real, practical guides that connect to Prilosec and the issues it treats. You’ll see comparisons between acid reflux meds, tips for managing GERD without pills, and how other medications interact with stomach acid reducers. There’s also advice on spotting when your symptoms need more than just an OTC pill — because sometimes, heartburn is a sign of something bigger.